What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
Identifieur interne : 002674 ( Main/Exploration ); précédent : 002673; suivant : 002675What is the evidence of a role for host genetics in susceptibility to influenza A/H5N1?
Auteurs : P. Horby [Viêt Nam, Royaume-Uni] ; H. Sudoyo [Indonésie] ; V. Viprakasit ; A. Fox [Viêt Nam, Royaume-Uni] ; P. Q. Thai [Viêt Nam] ; H. Yu [République populaire de Chine] ; S. Davila [Singapour] ; M. Hibberd [Singapour] ; S. J. Dunstan [Viêt Nam, Royaume-Uni] ; Y. Monteerarat ; J. J. Farrar [Viêt Nam, Royaume-Uni] ; S. Marzuki [Indonésie] ; N. T. Hien [Viêt Nam]Source :
- Epidemiology and Infection [ 0950-2688 ] ; 2010-11.
Abstract
The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.
Url:
DOI: 10.1017/S0950268810000518
Affiliations:
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Thai</name><affiliation wicri:level="1"><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>National Institute for Hygiene and Epidemiology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author><author><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Centre for Disease Control and Prevention, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Davila, S" sort="Davila, S" uniqKey="Davila S" first="S." last="Davila">S. 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Dunstan</name><affiliation wicri:level="1"><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University</wicri:regionArea><wicri:noRegion>Oxford University</wicri:noRegion></affiliation></author><author><name sortKey="Monteerarat, Y" sort="Monteerarat, Y" uniqKey="Monteerarat Y" first="Y." last="Monteerarat">Y. Monteerarat</name><affiliation><wicri:noCountry code="subField">Bangkok</wicri:noCountry></affiliation></author><author><name sortKey="Farrar, J J" sort="Farrar, J J" uniqKey="Farrar J" first="J. J." last="Farrar">J. J. 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Hien</name><affiliation wicri:level="1"><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>National Institute for Hygiene and Epidemiology, Hanoi</wicri:regionArea><wicri:noRegion>Hanoi</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Epidemiology and Infection</title><title level="j" type="abbrev">Epidemiol. Infect.</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="2010-11">2010-11</date><biblScope unit="volume">138</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1550">1550</biblScope><biblScope unit="page" to="1558">1558</biblScope></imprint><idno type="ISSN">0950-2688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The apparent family clustering of avian influenza A/H5N1 has led several groups to postulate the existence of a host genetic influence on susceptibility to A/H5N1, yet the role of host factors on the risk of A/H5N1 disease has received remarkably little attention compared to the efforts focused on viral factors. We examined the epidemiological patterns of human A/H5N1 cases, their possible explanations, and the plausibility of a host genetic effect on susceptibility to A/H5N1 infection. The preponderance of familial clustering of cases and the relative lack of non-familial clusters, the occurrence of related cases separated by time and place, and the paucity of cases in some highly exposed groups such as poultry cullers, are consistent with a host genetic effect. Animal models support the biological plausibility of genetic susceptibility to A/H5N1. Although the evidence is circumstantial, host genetic factors are a parsimonious explanation for the unusual epidemiology of human A/H5N1 cases and warrant further investigation.</div></front></TEI><affiliations><list><country><li>Indonésie</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Singapour</li><li>Viêt Nam</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Monteerarat, Y" sort="Monteerarat, Y" uniqKey="Monteerarat Y" first="Y." last="Monteerarat">Y. Monteerarat</name><name sortKey="Viprakasit, V" sort="Viprakasit, V" uniqKey="Viprakasit V" first="V." last="Viprakasit">V. Viprakasit</name></noCountry><country name="Viêt Nam"><noRegion><name sortKey="Horby, P" sort="Horby, P" uniqKey="Horby P" first="P." last="Horby">P. Horby</name></noRegion><name sortKey="Dunstan, S J" sort="Dunstan, S J" uniqKey="Dunstan S" first="S. J." last="Dunstan">S. J. 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Fox</name></country><country name="Indonésie"><noRegion><name sortKey="Sudoyo, H" sort="Sudoyo, H" uniqKey="Sudoyo H" first="H." last="Sudoyo">H. Sudoyo</name></noRegion><name sortKey="Marzuki, S" sort="Marzuki, S" uniqKey="Marzuki S" first="S." last="Marzuki">S. Marzuki</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Yu, H" sort="Yu, H" uniqKey="Yu H" first="H." last="Yu">H. Yu</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Davila, S" sort="Davila, S" uniqKey="Davila S" first="S." last="Davila">S. Davila</name></noRegion><name sortKey="Hibberd, M" sort="Hibberd, M" uniqKey="Hibberd M" first="M." last="Hibberd">M. Hibberd</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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